How common is vitamin B - 12 deficiency ? 1 - 3
نویسنده
چکیده
In considering the vitamin B-12 fortification of flour, it is important to know who is at risk of vitamin B12 deficiency and whether those individuals would benefit from flour fortification. This article reviews current knowledge of the prevalence and causes of vitamin BI 2 deficiency and considers whether fortification would improve the status of deficient subgroups of the population. In large surveys in the United States and the United Kingdom, '6% of those aged >60 y are vitamin B-12 deficient (plasma vitamin B12< 148 pmolIL), with the prevalence of deficiency increasing with age. Closer to 20% have marginal status (plasma vitamin B-12: 148-221 pmol/L) in later life. In developing countries, deficiency is much more common, starting in early life and persisting across the life span. Inadequate intake, due to low consumption of animal-source foods, is the main cause of low serum vitamin B-12 in younger adults and likely the main cause in poor populations worldwidc in most studies, serum vitamin B-12 concentration is correlated with intake of this vitamin. In older persons, food-hound cobalamin malabsorption becomes the predominant cause of deficiency, at least in part due to gastric atrophy, but it is likely that most elderly can absorb the vitamin from fortified food. Fortification of flout, with vitamin B-12 is likely to improve the status of most persons with low stores of this vitamin. However, intervention studies are still needed to assess efficacy and functional benefits of increasing intake of the amounts likely to be consumed in flour, including in elderly persons with varying degrees of gastric atrophy. Am J C/in Nutr 2009:89(suppl):693S-6S.
منابع مشابه
Vitamin B12 deficiency.
Haematology, Guy’s and St Thomas’ NHS Foundation Trust, London, UK Correspondence to: A Hunt [email protected] Cite this as: BMJ 2014;349:g5226 doi: 10.1136/bmj.g5226 Vitamin B12 is an essential cofactor that is integral to methylation processes important in reactions related to DNA and cell metabolism, thus a deficiency may lead to disruption of DNA and cell metabolism and thus have serious c...
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